On the Basis of Physical Properties of Drugs

The following points help to understand the nature of drugs in a better manner:

Physical State of Drug : At room temperature, drugs may either be in the form of solid (e.g., aspirin, atropine), liquids (e.g., nicotine, ethanol), or gases (e.g., nitrous oxide). The route which is the best for its administration is often determined by these factors. In pharmacology, different classes of organic compounds like carbohydrates, proteins, lipids, and their constituents, all are included.

Many inorganic substances, e.g. lithium, iron. heavy metals, etc., may be proven useful or dangerous. Numerous organic drugs are weakly acidic or basic in nature.

The nature of the drugs plays an important role in determining the manner in which their action is controlled by the body. This is because the degree of ionisation of such drugs may be modified by the varying pH. within different sections of the body.

Drug Size : The variation in the size of the molecules of drugs ranges from very small (lithium ion, MW 7) to very large (e.g., alteplase [t-PA], a protein of MW 59.050). though, most of them possess molecular weights between 100 and 1000.

A molecule of drug must be sufficiently unique in shape, charge, and other properties in order to be apt to only one type of receptor (to have a good “fit” to only one type of receptor), so that its binding with other receptors can be prevented.

To achieve such selective binding, it appears that a molecule should in most cases be at least 100MW units in size. The ability of a molecule to be transported within the body (e.g., from the site of administration to the site of action) governs its upper limit in terms of molecular weight.

Drugs that have molecular weight greater than 1000 are insufficiently diffused between various sections of the body. Hence, administration of drugs that are very large in size (usually proteins) must be done directly into the section where their action is desired.

Drug Reactivity and Drug-Receptor Bonds : Chemical forces or bonds play a role when the drug interacts with its receptor.

The bond between a drug and receptor can be of mainly three types:

Covalent Bonds : Covalent bonds are very strong bonds, as well as also irreversible under biological conditions, in many cases. The drugs that form covalent bonds are highly reactive, e.g., disruption of cell division in the tumour by the DNA-alkylating agents used in cancer chemotherapy.

Electrostatic Bonding : Drug-receptor interactions show electrostatic bonding more commonly than covalent bonding. Variation is seen in electrostatic bonds ranging from, relatively strong bonds between permanently charged ionic molecules to weaker hydrogen bonds and very weak bonds that can be seen in induced dipole interactions (such as Vander Waals forces and similar phenomena). Nevertheless, covalent bonds are stronger than electrostatic bonds.

Hydrophobic Bonds : Hydrophobic bonds are weak bonds. They play an important role in the interaction between highly lipid-soluble drugs and the lipids of cell membranes as well as in the interaction between drugs and the internal walls of receptor ‘pockets’.

Drug Shape : The shape of a molecule of drug should be such that it permits binding to the receptor site through bonds. The shape of a drug should be compliment to that of the receptor site, just in the same way as a key complements a lock.

Rational Drug Design : The ability to predict the appropriate molecular structure of a drug on the basis of biological receptor is denoted by the rational drug design. Though, many receptors have been isolated and were observed during the past three decades, yet such a drug design was not permitted until the recent times, as the appropriate detail of none of the receptors was known.

Based on the knowledge of the three-dimensional structure of the receptor site, the molecular designs of a few drugs which are now in use have been developed. Optimisation of drug structures to fit known receptors has now been possible with the use of the computer programmes available. With more knowledge on the receptor structure, rational drug design will eventually gain popularity.

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Santhakumar Raja

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